| Result | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| Loss | 5–2 | Cain Velasquez | TKO (Strikes) | UFC 121: Lesnar vs. Velasquez | October 23, 2010 | 1 | 4:12 | Anaheim, California | Lost UFC Heavyweight Championship |
| Win | 5–1 | Shane Carwin | Submission (Arm Triangle Choke) | UFC 116: Lesnar vs. Carwin | July 3, 2010 | 2 | 2:19 | Las Vegas, Nevada | Defended UFC Heavyweight Championship to become the Undisputed Champion. Submission of the Night |
| Win | 4–1 | Frank Mir | TKO (Punches) | UFC 100 | July 11, 2009 | 2 | 1:48 | Las Vegas, Nevada | Defended UFC Heavyweight Championship to become the Undisputed Champion |
| Win | 3–1 | Randy Couture | TKO (Strikes) | UFC 91: Couture vs. Lesnar | November 15, 2008 | 2 | 3:07 | Las Vegas, Nevada | Won UFC Heavyweight Championship. |
| Win | 2–1 | Heath Herring | Decision (Unanimous) | UFC 87: Seek and Destroy | August 9, 2008 | 3 | 5:00 | Minneapolis, Minnesota | |
| Loss | 1–1 | Frank Mir | Submission (Kneebar) | UFC 81: Breaking Point | February 2, 2008 | 1 | 1:30 | Las Vegas, Nevada | UFC Debut |
| Win | 1–0 | Min-Soo Kim | Submission (Punches) | Dynamite!! USA | June 2, 2007 | 1 | 1:09 | Los Angeles, California | MMA Debut |
