| Result | Record | Opponent | Event | Date | Method | Round | Time | Location | Notes |
| Loss | 21–8 | Rich Franklin | KO (Punch) | UFC 115: Liddell vs. Franklin | June 12, 2010 | 1 | 4:55 | Vancouver, Canada | |
| Loss | 21–7 | Mauricio Rua | KO (Strikes) | UFC 97: Redemption | April 18, 2009 | 1 | 4:28 | Montreal, Canada | |
| Loss | 21–6 | Rashad Evans | KO (Punch) | UFC 88: Breakthrough | September 6, 2008 | 2 | 1:51 | Atlanta, Georgia | |
| Win | 21–5 | Wanderlei Silva | Decision (Unanimous) | UFC 79: Nemesis | December 29, 2007 | 3 | 5:00 | Las Vegas, Nevada | Fight of the Night. Awarded fight of the year 2008 by World MMA Awards. |
| Loss | 20–5 | Keith Jardine | Decision (Split) | UFC 76: Knockout | September 22, 2007 | 3 | 5:00 | Anaheim, California | |
| Loss | 20–4 | Quinton Jackson | TKO (Punches) | UFC 71: Liddell vs. Jackson | May 26, 2007 | 1 | 1:53 | Las Vegas, Nevada | Lost UFC Light Heavyweight Championship |
| Win | 20–3 | Tito Ortiz | TKO (Punches) | UFC 66: Liddell vs. Ortiz 2 | December 30, 2006 | 3 | 3:59 | Las Vegas, Nevada | Defended UFC Light Heavyweight Championship |
| Win | 19–3 | Renato Sobral | KO (Punches) | UFC 62: Liddell vs. Sobral | August 26, 2006 | 1 | 1:35 | Las Vegas, Nevada | Defended UFC Light Heavyweight Championship |
| Win | 18–3 | Randy Couture | KO (Punches) | UFC 57: Liddell vs. Couture 3 | February 4, 2006 | 2 | 1:28 | Las Vegas, Nevada | Defended UFC Light Heavyweight Championship |
| Win | 17–3 | Jeremy Horn | Verbal Submission (Blurred Vision) | UFC 54: Boiling Point | August 20, 2005 | 4 | 2:46 | Las Vegas, Nevada | Defended UFC Light Heavyweight Championship |
| Win | 16–3 | Randy Couture | KO (Punches) | UFC 52: Couture vs Liddell 2 | April 16, 2005 | 1 | 2:06 | Las Vegas, Nevada | Won UFC Light Heavyweight Championship |
| Win | 15–3 | Vernon White | KO (Punch) | UFC 49: Unfinished Business | August 21, 2004 | 1 | 4:05 | Las Vegas, Nevada | |
| Win | 14–3 | Tito Ortiz | KO (Punches) | UFC 47: It's On! | April 2, 2004 | 2 | 0:38 | Las Vegas, Nevada | |
| Loss | 13–3 | Quinton Jackson | TKO (Corner Stoppage) | PRIDE Final Conflict 2003 | November 9, 2003 | 2 | 3:10 | Tokyo, Japan | Pride Middleweight Grand Prix Semifinal |
| Win | 13–2 | Alistair Overeem | KO (Punches) | PRIDE Total Elimination 2003 | August 10, 2003 | 1 | 3:09 | Saitama, Japan | Pride Middleweight Grand Prix Quarterfinal |
| Loss | 12–2 | Randy Couture | TKO (Punches) | UFC 43: Meltdown | June 6, 2003 | 3 | 2:39 | Las Vegas, Nevada | For Interim UFC Light Heavyweight Championship |
| Win | 12–1 | Renato Sobral | KO (Head Kick and Punches) | UFC 40: Vendetta | November 22, 2002 | 1 | 2:55 | Las Vegas, Nevada | |
| Win | 11–1 | Vitor Belfort | Decision (Unanimous) | UFC 37.5: As Real As It Gets | June 22, 2002 | 3 | 5:00 | Las Vegas, Nevada | |
| Win | 10–1 | Amar Suloev | Decision (Unanimous) | UFC 35: Throwdown | January 11, 2002 | 3 | 5:00 | Uncasville, Connecticut | |
| Win | 9–1 | Murilo Bustamante | Decision (Unanimous) | UFC 33: Victory in Vegas | September 28, 2001 | 3 | 5:00 | Las Vegas, Nevada | |
| Win | 8–1 | Guy Mezger | KO (Punch) | PRIDE 14: Clash of the Titans| | May 27, 2001 | 2 | 0:21 | Yokohama, Japan | |
| Win | 7–1 | Kevin Randleman | KO (Punches) | UFC 31: Locked and Loaded | May 4, 2001 | 1 | 4:05 | Atlantic City, New Jersey | |
| Win | 6–1 | Jeff Monson | Decision (Unanimous) | UFC 29: Defense of the Belts | December 6, 2000 | 3 | 5:00 | Tokyo, Japan | |
| Win | 5–1 | Steve Heath | KO (Head Kick) | IFC WC 9 – Warriors Challenge 9 | July 18, 2000 | 2 | 5:39 | Friant, California | |
| Win | 4–1 | Paul Jones | TKO (Strikes) | UFC 22: Only One Can be Champion | September 24, 1999 | 1 | 3:53 | Lake Charles, Louisiana | |
| Win | 3–1 | Kenneth Williams | Submission (Rear-Naked Choke) | NG 11 – Neutral Grounds 11 | March 31, 1999 | 1 | 3:10 | Los Angeles, California | |
| Loss | 2–1 | Jeremy Horn | Technical Submission (Arm Triangle Choke) | UFC 19: Ultimate Young Guns | March 5, 1999 | 1 | 12:00 | Bay St. Louis, Mississippi | |
| Win | 2–0 | Jose Landi-Jons | Decision (Unanimous) | IVC 6 – The Challenge | August 23, 1998 | 1 | 30:00 | São Paulo, Brazil | |
| Win | 1–0 | Noe Hernandez | Decision (Unanimous) | UFC 17: Redemption | May 15, 1998 | 1 | 12:00 | Mobile, Alabama | |
