| Result | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| Win | 14–5 | Mirko Filipović | KO (Knee) | UFC 119: Mir vs. Cro Cop | September 25, 2010 | 3 | 4:02 | Indianapolis, Indiana | |
| Loss | 13–5 | Shane Carwin | KO (Punches) | UFC 111: St-Pierre vs Hardy | March 27, 2010 | 1 | 3:48 | Newark, New Jersey | For UFC Interim Heavyweight Championship. |
| Win | 13–4 | Cheick Kongo | Technical Submission (Guillotine Choke) | UFC 107: Penn vs. Sanchez | December 12, 2009 | 1 | 1:12 | Memphis, Tennessee | |
| Loss | 12–4 | Brock Lesnar | TKO (Punches) | UFC 100 | July 11, 2009 | 2 | 1:48 | Las Vegas | For Unified UFC Heavyweight Championship. |
| Win | 12–3 | Antônio Rodrigo Nogueira | TKO (Punches) | UFC 92: The Ultimate 2008 | December 27, 2008 | 2 | 1:57 | Las Vegas | Won UFC Interim Heavyweight Championship. |
| Win | 11–3 | Brock Lesnar | Submission (Kneebar) | UFC 81: Breaking Point | February 2, 2008 | 1 | 1:30 | Las Vegas | Submission of the Night. |
| Win | 10–3 | Antoni Hardonk | Submission (Kimura) | UFC 74: Respect | August 25, 2007 | 1 | 1:17 | Las Vegas | |
| Loss | 9–3 | Brandon Vera | TKO (Punches) | UFC 65: Bad Intentions | November 18, 2006 | 1 | 1:09 | Sacramento, California | |
| Win | 9–2 | Dan Christison | Decision (Unanimous) | UFC 61: Bitter Rivals | July 8, 2006 | 3 | 5:00 | Las Vegas | |
| Loss | 8–2 | Marcio Cruz | TKO (Punches) | UFC 57: Liddell vs. Couture 3 | February 4, 2006 | 1 | 4:10 | Las Vegas | First fight after the motorcycle accident. |
| Win | 8–1 | Tim Sylvia | Technical Submission (Armbar) | UFC 48: Payback | June 19, 2004 | 1 | 0:50 | Las Vegas | Won UFC Heavyweight Championship. Later stripped of title when he was unable to defend it. |
| Win | 7–1 | Wes Sims | KO (Strikes) | UFC 46: Supernatural | January 31, 2004 | 2 | 4:21 | Las Vegas, Nevada | |
| Win | 6–1 | Wes Sims | DQ (Stomping a Downed Opponent) | UFC 43: Meltdown | June 6, 2003 | 1 | 2:55 | Las Vegas, Nevada | |
| Win | 5–1 | Tank Abbott | Submission (Toe Hold) | UFC 41: Onslaught | February 28, 2003 | 1 | 0:46 | Atlantic City, New Jersey | |
| Loss | 4–1 | Ian Freeman | TKO (Punches) | UFC 38: Brawl at the Hall | July 13, 2002 | 1 | 4:35 | London, England | |
| Win | 4–0 | Pete Williams | Submission (Inside Shoulder Lock) | UFC 36: Worlds Collide | March 22, 2002 | 1 | 0:46 | Las Vegas, Nevada | Pete Williams retired after the bout. |
| Win | 3–0 | Roberto Traven | Submission (Armbar) | UFC 34: High Voltage | November 2, 2001 | 1 | 1:05 | Las Vegas | |
| Win | 2–0 | Dan Quinn | Submission (Triangle Choke) | IFC Warriors Challenge 15 | August 31, 2001 | 1 | 2:15 | Oroville, California | |
| Win | 1–0 | Jerome Smith | Decision (Unanimous) | HOOKnSHOOT – Showdown | July 14, 2001 | 2 | 5:00 | Evansville, Indiana | |
