| Result | Record | Opponent | Event | Date | Method | Round | Time | Location | Notes |
| Loss | 16-2 | Quinton Jackson | Decision (Split) | UFC 123: Rampage vs. Machida | November 20, 2010 | 3 | 5:00 | Auburn Hills, Michigan | |
| Loss | 16-1 | Maurício Rua | KO (Punches) | UFC 113: Machida vs. Shogun 2 | May 8, 2010 | 1 | 3:35 | Montreal, Quebec | Lost UFC Light Heavyweight Championship |
| Win | 16-0 | Maurício Rua | Decision (Unanimous) | UFC 104: Machida vs. Shogun | October 24, 2009 | 5 | 5:00 | Los Angeles, California, US | Defended UFC Light Heavyweight Championship |
| Win | 15–0 | Rashad Evans | KO (Punches) | UFC 98: Evans vs. Machida | May 23, 2009 | 2 | 3:57 | Las Vegas, Nevada | Won UFC Light Heavyweight Championship. Knockout of the Night. |
| Win | 14–0 | Thiago Silva | KO (Punch) | UFC 94: St-Pierre vs. Penn 2 | January 31, 2009 | 1 | 4:59 | Las Vegas, Nevada | Knockout of the Night. |
| Win | 13–0 | Tito Ortiz | Decision (Unanimous) | UFC 84: Ill Will | May 24, 2008 | 3 | 5:00 | Las Vegas, Nevada | |
| Win | 12-0 | Rameau Thierry Sokoudjou | Submission (Arm-Triangle Choke) | UFC 79: Nemesis | December 29, 2007 | 2 | 4:20 | Las Vegas, Nevada | |
| Win | 11–0 | Kazuhiro Nakamura | Decision (Unanimous) | UFC 76: Knock-Out | September 22, 2007 | 3 | 5:00 | Anaheim, California | |
| Win | 10–0 | David Heath | Decision (Unanimous) | UFC 70: Nations Collide | April 21, 2007 | 3 | 5:00 | Manchester, England, UK | |
| Win | 9–0 | Sam Hoger | Decision (Unanimous) | UFC 67: All or Nothing | February 3, 2007 | 3 | 5:00 | Las Vegas, Nevada | UFC debut |
| Win | 8–0 | Vernon White | Decision (Unanimous) | WFA: King of the Streets | July 22, 2006 | 3 | 5:00 | Los Angeles, California | |
| Win | 7–0 | Dimitri Wanderley | TKO (Exhaustion) | Jungle Fight 6 | April 29, 2006 | 3 | 3:24 | Manaus, Brazil | |
| Win | 6–0 | B.J. Penn | Decision (Unanimous) | K-1 Hero's 1 | March 26, 2005 | 3 | 5:00 | Saitama, Japan | Machida fought at a weight of 102.0 kg (225 lb). Penn weighed in at 86.5 kg (191 lb).[62] |
| Win | 5–0 | Sam Greco | Decision (Split) | K-1 MMA ROMANEX | May 22, 2004 | 3 | 5:00 | Saitama, Japan | |
| Win | 4–0 | Michael McDonald | Submission (Forearm Choke) | K-1 Beast 2004 in Niigata | March 14, 2004 | 1 | 2:30 | Saitama, Japan | |
| Win | 3–0 | Rich Franklin | KO (Head Kick and Punches) | Inoki Bom-Ba-Ye 2003-Inoki Festival | December 31, 2003 | 2 | 1:03 | Kobe, Japan | |
| Win | 2–0 | Stephan Bonnar | TKO (Cut) | Jungle Fight 1 | September 13, 2003 | 1 | 4:21 | Manaus, Brazil | |
| Win | 1–0 | Kengo Watanabe | Decision (Unanimous) | NJPW: Ultimate Crush | May 2, 2003 | 3 | 5:00 | Tokyo, Japan | |
