| Result | Record | Opponent | Method | Round | Time | Date | Event | Location | Notes |
| Loss | 45-8 | BJ Penn | KO (Punches) | 1 | 0:21 | 2010-11-20 | UFC 123: Rampage vs. Machida | Auburn Hills, Michigan | |
| Win | 45-7 | Ricardo Almeida | Technical Submission (Front Headlock Choke) | 1 | 3:15 | 2010-08-07 | UFC 117: Silva vs. Sonnen | Oakland, California | Submission of the Night |
| Win | 44-7 | Renzo Gracie | TKO (Punches) | 3 | 4:40 | 2010-04-10 | UFC 112: Invincible | Abu Dhabi, UAE | |
| Win | 43-7 | Matt Serra | Decision (unanimous) | 3 | 5:00 | 2009-05-23 | UFC 98: Evans vs. Machida | Las Vegas, Nevada | Fight of the Night |
| Loss | 42-7 | Thiago Alves | TKO (Flying Knee and Punches) | 2 | 1:02 | 2008-06-07 | UFC 85: Bedlam | London England, UK | Catchweight fight; Alves weighed 174 lbs. |
| Loss | 42-6 | Georges St-Pierre | Submission (armbar) | 2 | 4:54 | 2007-12-29 | UFC 79: Nemesis | Las Vegas, Nevada | For UFC Interim Welterweight Championship |
| Win | 42-5 | Chris Lytle | Decision (unanimous) | 3 | 5:00 | 2007-03-03 | UFC 68: The Uprising | Columbus, Ohio | |
| Loss | 41-5 | Georges St-Pierre | TKO (Head Kick and Punches) | 2 | 1:25 | 2006-11-18 | UFC 65: Bad Intentions | Sacramento, California | Lost UFC Welterweight Championship |
| Win | 41-4 | B.J. Penn | TKO (Punches) | 3 | 3:53 | 2006-09-23 | UFC 63: Hughes vs. Penn 2 | Anaheim, California | Defended UFC Welterweight Championship |
| Win | 40-4 | Royce Gracie | TKO (Punches) | 1 | 4:39 | 2006-05-27 | UFC 60: Hughes vs. Gracie | Los Angeles, California | 175 lb. Catchweight, non-title fight |
| Win | 39-4 | Joe Riggs | Submission (kimura) | 1 | 3:26 | 2005-11-19 | UFC 56: Full Force | Las Vegas, Nevada | Non-title fight; Riggs (replacing Karo Parisyan on short notice) failed to make weight |
| Win | 38-4 | Frank Trigg | Submission (rear naked choke) | 1 | 4:05 | 2005-04-16 | UFC 52: Couture vs. Liddell 2 | Las Vegas, Nevada | Defended UFC Welterweight Championship |
| Win | 37-4 | Georges St-Pierre | Submission (armbar) | 1 | 4:59 | 2004-10-22 | UFC 50: The War of '04 | Atlantic City, New Jersey | Won UFC Welterweight Championship |
| Win | 36-4 | Renato Verissimo | Decision (unanimous) | 3 | 5:00 | 2004-06-19 | UFC 48: Payback | Las Vegas, Nevada | |
| Loss | 35-4 | B.J. Penn | Submission (rear naked choke) | 1 | 4:39 | 2004-01-31 | UFC 46: Supernatural | Las Vegas, Nevada | Lost UFC Welterweight Championship |
| Win | 35-3 | Frank Trigg | Submission (rear naked choke) | 1 | 3:54 | 2003-11-21 | UFC 45: Revolution | Uncasville, Connecticut | Defended UFC Welterweight Championship |
| Win | 34-3 | Sean Sherk | Decision (unanimous) | 5 | 5:00 | 2003-04-25 | UFC 42: Sudden Impact | Miami, Florida | Defended UFC Welterweight Championship |
| Win | 33-3 | Gil Castillo | TKO (doctor stoppage) | 1 | 5:00 | 2002-11-22 | UFC 40: Vendetta | Las Vegas, Nevada | Defended UFC Welterweight Championship |
| Win | 32-3 | Carlos Newton | TKO (strikes) | 4 | 3:27 | 2002-07-13 | UFC 38: Brawl at the Hall | London, England, UK | Defended UFC Welterweight Championship |
| Win | 31-3 | Hayato Sakurai | TKO (strikes) | 4 | 3:01 | 2002-03-22 | UFC 36: Worlds Collide | Las Vegas, Nevada | Defended UFC Welterweight Championship |
| Win | 30-3 | Carlos Newton | KO (slam) | 2 | 1:27 | 2001-11-02 | UFC 34: High Voltage | Las Vegas, Nevada | Won UFC Welterweight Championship |
| Win | 29-3 | Steve Gomm | TKO | 2 | 3:18 | 2001-09-08 | Extreme Challenge 43 | Orem, Utah | |
| Win | 28-3 | Hiromitsu Kanehara | Decision (majority) | 3 | 5:00 | 2001-08-11 | RINGS: 10th Anniversary | Tokyo, Japan | |
| Win | 27-3 | Chatt Lavender | Submission (side choke) | 3 | 2:31 | 2001-07-13 | Extreme Challenge 41 | Davenport, Iowa | |
| Win | 26-3 | Scott Johnson | KO (Punch) | 1 | 3:24 | 2001-06-16 | Extreme Challenge 40 | Springfield, Illinois | |
| Win | 25-3 | John Cronk | Submission (strikes) | N/A | 2001-05-11 | Gladiators 14 | Omaha, Nebraska | |
| Win | 24-3 | Bruce Nelson | Submission (strikes) | 1 | 3:01 | 2001-03-31 | Freestyle Combat Challenge 4 | Racine, Wisconsin | |
| Win | 23-3 | Brett Al-azzawi | Submission (armbar) | 1 | 3:27 | 2001-03-17 | RINGS USA: Battle of Champions | Council Bluffs, Iowa | |
| Loss | 22-3 | Jose Landi-Jons | TKO (Knee to the Head) | 1 | 4:45 | 2001-02-08 | Shidokan Jitsu: Warriors War 1 | Kuwait | |
| Loss | 22-2 | Dennis Hallman | Submission (armbar) | 1 | 0:20 | 2000-12-16 | UFC 29: Defense of the Belts | Tokyo, Japan | |
| Win | 22-1 | Maynard Marcum | Submission (keylock) | 1 | 6:29 | 2000-11-12 | RINGS Australia: Free Fight Battle | Brisbane, Australia | |
| Win | 21-1 | Robbie Newman | Submission (arm triangle choke) | 1 | 1:40 | 2000-09-30 | RINGS USA: Rising Stars Final | Moline, Illinois | |
| Win | 20-1 | Chris Haseman | Decision (unanimous) | 2 | 5:00 | 2000-08-23 | RINGS: Millennium Combine 3 | Osaka, Japan | |
| Win | 19-1 | Joe Guist | Submission (armbar) | 1 | 2:45 | 2000-06-29 | Extreme Challenge 35 | Davenport, Iowa | |
| Win | 18-1 | Marcelo Aguiar | TKO (strikes) | 1 | 4:34 | 2000-06-09 | UFC 26: Ultimate Field of Dreams | Cedar Rapids, Iowa | |
| Win | 17-1 | Shawn Peters | Submission (arm triangle choke) | 1 | 2:52 | 2000-05-21 | Extreme Challenge 32 | Springfield, Illinois | |
| Win | 16-1 | Alexandre Barros | Decision (unanimous) | 3 | 5:00 | 2000-05-13 | WEF 9: World Class | Evansville, Indiana | |
| Win | 15-1 | Eric DaVila | Submission (keylock) | 2 | 3:24 | 2000-04-15 | SuperBrawl 17 | Honolulu, Hawaii | |
| Win | 14–1 | Jorge Pereira | TKO (cut) | 1 | 6:00 | 2000-01-15 | WEF 8: Goin' Platinum | Rome, Georgia | |
| Win | 13–1 | Daniel Vianna | KO (slam) | 1 | 2:16 | 1999-11-20 | JKD Challenge 3 | Chicago, Illinois | |
| Win | 12–1 | Laverne Clark | Submission (rear naked choke) | 2 | 1:35 | 1999-11-13 | Extreme Challenge 29 | Hayward, Wisconsin | |
| Win | 11–1 | Tom Schmitz | Submission (eye injury) | 1 | 0:48 | 1999-11-13 | Extreme Challenge 29 | Hayward, Wisconsin | |
| Win | 10–1 | Joe Doerksen | Submission (strikes) | 2 | 0:25 | 1999-11-13 | Extreme Challenge 29 | Hayward, Wisconsin | |
| Win | 9–1 | Valeri Ignatov | Decision (unanimous) | 3 | 5:00 | 1999-09-24 | UFC 22: Only One Can Be Champion | Lake Charles, Louisiana | UFC debut |
| Win | 8–1 | Akihiro Gono | Decision (unanimous) | 3 | 5:00 | 1999-05-29 | Shooto: 10th Anniversary Event | Yokohama, Japan | |
| Win | 7–1 | Erick Snyder | TKO (slam) | N/A | 1999-04-24 | Jeet Kune Do Challenge 4 | Chicago, Illinois | |
| Win | 6–1 | Joe Stern | Submission (strikes) | 1 | 2:30 | 1999-04-02 | Extreme Challenge 23 | Indianapolis, Indiana | |
| Win | 5–1 | Ryan Stout | TKO (towel) | 2 | 5:00 | 1998-12-11 | Extreme Shootfighting | Waukesha, Wisconsin | |
| Loss | 4–1 | Dennis Hallman | Technical Submission (guillotine choke) | 1 | 0:18 | 1998-10-17 | Extreme Challenge 21 | Hayward, Wisconsin | |
| Win | 4–0 | Dave Menne | Decision (unanimous) | 1 | 15:00 | 1998-10-17 | Extreme Challenge 21 | Hayward, Wisconsin | |
| Win | 3–0 | Victor Hunsaker | TKO (strikes) | 1 | 1:39 | 1998-10-17 | Extreme Challenge 21 | Hayward, Wisconsin | |
| Win | 2–0 | Craig Quick | Submission (strikes) | N/A | 1998-04-25 | Jeet Kune Do Challenge 1 | Chicago, Illinois | |
| Win | 1–0 | Erick Snyder | Submission (Slam) | 1 | 0:15 | 1998-01-01 | JKD – Challenge 2 | Chicago, Illinois | |
